[Statlist] Special talk

[Christina Kuenzli]

                       ETH and University of Zurich 
      Proff. A.D. Barbour -- P. Buehlmann -- F. Hampel -- H.R. Kuensch 

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           We are pleased to announce the following special talk
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Monday, July 12, 2004, 16.15, LEO C 15
       
      Chiara Sabatti
      Department of Human Genetics and Statistics, UCLA, Los Angeles

      A bioinformatics approach to transcription regulation in E. Coli         

Transcription regulation is the first step in the control of
gene expression. Transcription factors bind in the DNA region up-stream
the genes they regulate and they can either induce or suppress
transcription. A study of non-coding DNA sequence can provide
information on the presence of these binding sites and hence help
determine which genes are regulated by which protein. This information
can then be related to measurements on mRNA levels obtained via gene
expression arrays: activation of transcription factors can be inferred
and presence of binding sites confirmed or disproved.
I will describe a dictionary model (Vocabulon) for the identification of
binding sites of regulatory proteins in genomic sequence and a Bayesian
model for regulatory networks that takes the results of Vocabulon as
input. Both algorithms are tested in E. Coli, where they achieve
appreciable results.

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(LEO (Leonhardstrasse 27, 8006 Zurich) is close to the main building,
across the hill-side station of the 'Polybahn') 
Overview maps of ETH : http://www.ethz.ch/search/orientation_en.asp

Further information: Christina Kuenzli, Statistics Seminar of ETH Zurich 
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Everybody is kindly invited
 
Eidgenoessische Technische Hochschule Zuerich
Swiss Federal Insitute of Technology Zurich

________________________________________________________
Christina Kuenzli            <kuenzli at stat.math.ethz.ch>
Seminar fuer Statistik      
Leonhardstr. 27,  LEO D11          phone: +41 1 632 3438         
ETH-Zentrum,                       fax  : +41 1 632 1228 
CH-8092 Zurich, Switzerland        http://stat.ethz.ch/~