[Statlist] Talk on Statistics

[Cecilia Rey]

                        ETH and University of Zurich

          Proff. A.D. Barbour - P. Buehlmann -  L. Held -
          H.R. Kuensch - M. Maathuis - W. Stahel - S. van de Geer


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          We are glad to announce the following talk
          Friday, February 27, 15.15-17.00  HG  G 19.1

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with Bernhard Renard, Universität Heidelberg 

Title:
Computational Protein Coregulation Screening for Quantitative Mass 
Spectrometry Experiments

Abstract:
The characterization of enzyme substrate specificity is a key step for 
understanding protein interaction in cellular pathways. In complex, 
real-world quantitative mass spectrometry experiments the exhaustive 
detection of substrates of an enzyme is non-trivial: manual biological 
validation of the substrate properties of all proteins present in a 
sample is plainly infeasible. A suitable approach to this problem is a 
rigorous screening procedure that determines the similarity of relative 
peptide measurements using compositional data analysis procedures and 
aggregates these peptide level results to obtain a shortlist of proteins 
ranked by their abundance level similarity to a known substrate. For 
data acquired over a time-course or over a set of environmental 
conditions, such a procedure provides suitable enrichment and 
prioritization of co-active candidates for biological validation.

The abstract can also be found under the following link:  
http://stat.ethz.ch/talks/research_seminar

Listeners are welcome!

-- 
ETH Zürich
Seminar für Statistik
Cecilia Rey-Lutz, HG G10.3
Rämistrasse 101                    
CH-8092 Zurich		                      	
mail: rey at stat.math.ethz.ch    	  		
phone: +41 44 632 3438/fax: +41 44 632 1228